Design, implement, and run automated benchmarking and validation pipelines for AI-driven genomic interpretation. Expand regression datasets, execute large-scale validation across curated VCFs, surface accuracy regressions, build automated QA for AI releases, and integrate validation into CI/CD with dashboards and documented failure modes.
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
At Sequencing, you'll build and operate the evaluation and validation infrastructure that keeps our AI systems correct, reliable, and regression-protected. This is an execution-focused role: you'll design, implement, and maintain the benchmarking systems that continuously test AI outputs against curated genomic datasets, partnering closely with the AI Bioinformatics Engineering Lead to turn interpretation standards into measurable, operational systems. You are detail-oriented, have a systems-thinking mindset and you notice the one VCF out of ten thousand that doesn't look right
The Opportunity
- Build and run automated evaluation pipelines for AI outputs end-to-end.
- Expand regression datasets that cover variant normalization, transcript ambiguity, and disease-level mapping.
- Execute large-scale validation runs across curated VCF datasets, track performance over time, and surface accuracy regressions the moment they appear.
- Grow a structured question bank using and related datasets, encoding the edge cases that matter most.
- Ship automated regression tests for every AI release and build dashboards that make variant-level and case-level accuracy visible to the whole team.
- Partner with engineering to wire validation directly into CI/CD, and diagnose and document failure modes as they emerge.
Who you are
- Degree in Bioinformatics, Computational Biology, Genetics, or a related field.
- Deep, hands-on experience with VCFs and real-world genomic datasets.
- Fluency with ClinVar, dbSNP, HGVS standards, and transcript mapping.
- A track record building evaluation frameworks or testing pipelines, Langfuse or similar.
- Experience evaluating LLM-based systems and standing up automated QA at scale.
.
Include "kitten" in your resume
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected].
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process.
All legitimate Sequencing roles are posted on our official careers page and require you to apply through our company application portal. If a role claiming to be with Sequencing asks you to apply or communicate outside of those channels, it is not an authentic opportunity with our team. During our hiring process, we or our recruitment partners will never ask you to send money, purchase equipment, or share bank, credit card, or Social Security information before a verified offer. We also will not make same day offers without interviews or ask you to communicate only through informal messaging apps. If you believe someone is misusing our name in a fake posting, please report it to the job board or verify the posting by contacting [email protected].
Similar Jobs
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
The Account Executive will build a sales pipeline in the German markets, work with cross-functional teams, and maintain stakeholder relationships to drive sales and manage accounts for Deepgram's voice AI platform.
Top Skills:
AISales TechnologySpeech-To-SpeechSpeech-To-TextText-To-SpeechVoice Ai
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
Sell Deepgram's voice AI platform across EMEA by prospecting new logos, building pipeline, closing full-cycle technical deals, collaborating with Sales Ops and Sales Engineers, managing stakeholder relationships, and driving upsell with CSMs. Target technical buyers and communicate product value to meet and exceed quotas.
Top Skills:
Ai/MlCloud ApisDeveloper ToolsSpeech-To-TextText-To-SpeechVoice Ai
Edtech • Social Impact
Own end-to-end experience design for CodePath’s learning platform: map flows, navigation, and IA; build and maintain a design system; run product discovery with users and stakeholders; produce engineer-ready wireframes, prototypes, and specs; partner with PMs and engineers; and direct a UI contractor to deliver high-quality, consistent experiences.
Top Skills:
AIAnthropicClaudeCSSFigmaHTMLLlmTailwind
What you need to know about the Bristol Tech Scene
Along with Gloucester, Swindon and Bath, Bristol is part of the "Silicon Gorge" tech hub, a region in the U.K. renowned for its high-tech and research-driven industries, with a particular emphasis on sustainability and reducing environmental impact. As the European Green Capital, Bristol is home to 25,000 cleantech companies, including Baker Hughes and unicorn Ovo Energy. The city has committed to achieving net-zero emissions within the next decade.
